While Tom's very good at science, his brother is absolutely hopeless.

　　湯姆很擅長理科，而他的兄弟絕對是不可救藥。

　　This case is hopeless and he knows it.

　　這個案子毫無希望，這一點他是清楚的。

　　He's a hopeless case.

　　他是無可救藥了。

　　I'm hopeless at science.

　　我對理科一竅不通。

　　Our cat is hopeless at catching mice.

　　我們的貓絕對捉不到老鼠。

　　She felt lonely and hopeless.

　　她感到孤獨絕望。